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Wellness Foods + Supplements 3/2022

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Wellness Foods & Supplements is the first European magazine devoted exclusively to health ingredients, nutraceutical foods and beverages. Questions about the trade magazine Wellness Foods & Supplements? Interested in subscribing or advertising? The board of editors at Wellness Foods & Supplements kindly remains at your disposal.

Lactoferrin Lactoferrin

Lactoferrin Lactoferrin – also a real alternative for urinary tract infections A new preliminary study demonstrates the effect in cystitis Diana Kalustova Lactoferrin is a true all-rounder when it comes to treating various diseases and deficiency symptoms. As the name, composed of the Latin words milk and iron, suggests, the main function of lactoferrin is to bind and transport iron in the body. This special glycoprotein, which is found in mammals, for example in breast milk, and belongs to the transferrins, has antiviral as well as antimicrobial and antiinflammatory properties with its multifunctional enzyme activities. Effective from periodontitis to Alzheimer’s disease and infections The broad spectrum of activity of lactoferrin has been demonstrated in various studies for more than 100 years. As early as the beginning of the 21st century, lactoferrin was shown to have positive results in the treatment of chronic periodontitis. Since then, lactoferrin has demonstrated its efficacy in many areas. For example, a recent study* by neurologists in Cairo tested the effects of lactoferrin in Alzheimer’s patients. In this study, Alzheimer’s patients were treated with lactoferrin for 3 months and compared to both healthy patients and Alzheimer’s patients. Lactoferrin measurably reduced the levels of the disease markers amyloid-beta and tau proteins in Alzheimer’s patients. In addition, thinking performance improved after treatment. Lactoferrin also showed potential in the treatment of Covid-19. Preliminary results from a recently published meta study** in the U.K. show that lactoferrin has a detectable effect in reducing the risk of respiratory infection and also as a supplement in Covid-19. Recent study on positive effects in urinary tract infections A brand-new study*** on bovine lactoferrin (bLf) shows that there is much more to lactoferrin. It shows that this glycoprotein can be used as an alternative or adjunct to antibiotic treatments for urinary tract infections. A disease that affects more than 15 million people each year. Urinary tract infections (UTI) are most commonly caused by uropathogenic Escheria coli (UPEC) strains. Cystitis is defined as inflammation of the urinary bladder and is characterized by dysuria, frequent urination, and urinary urgency with or without suprapubic pain. 18 No. 3 November/Dezember 2022

Lactoferrin Supplementary Fig. S1. Incidence rate of cystitis before and after the date of enrolment by treatment groups. Data are expressed as events per 100 persons-month, and 95% confidence interval (CI). Given the fact that the number of patients treated with “bovine lactoferrin (bLf) + probiotics” and that of those treated with “bLf + probiotics + antibiotics” was relatively low (n=3 and n=5, respectively), these two groups were merged together (n=8) for the scope of this analysis. An effective antibiotic alternative The traditional treatment for urinary tract infections is antibiotic therapy. However, due to increasing bacterial resistance, effective non-antibiotic alternatives are being sought. The use of bLf as an alternative or complementary treatment to conventional antibiotics is based on its systemic effects in balancing, in particular, disturbances in iron and inflammatory homeostasis. What the tested bovine lactoferrin can do in this regard has now been investigated by several Italian scientists in a first study at the University of Rome. Lactoferrin in recurrent urinary tract infections: In vitro and in vivo evidence The bovine lactoferrin (bLf) study was conducted in patients with recurrent cystitis and showed a significant decrease in the number of such episodes over the observation period. Exceptionally positive results were observed both with bLf alone and as an adjunct to antibiotics, probiotics or both. The current, scientific findings are preliminary, promising studies whose results should be verified in further studies. Already today, the bovine lactoferrin under investigation is No. 3 November/Dezember 2022 19

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