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Wellness Foods + Supplements 3/2021

Wellness Foods & Supplements is the first European magazine devoted exclusively to health ingredients, nutraceutical foods and beverages. Questions about the trade magazine Wellness Foods & Supplements? Interested in subscribing or advertising? The board of editors at Wellness Foods & Supplements kindly remains at your disposal.

Healthy ageing and

Healthy ageing and mental well-being instance vitexin derivatives [27]. Extracts and tinctures of green oat have long been used to support the mental health. Indeed, extracts of Avena sativa L. have been implicated to modulate human brain function by interaction with neurotransmitter systems, since the enzymes monoamine oxidase B (MAO-B) and phosphodiesterase 4 (PDE-4) were inhibited by green oat extracts in in vitro bioactivity assays [27]. The effects of the green oat extract cognitaven ® on cognitive performance were recently examined in a randomised, double-blind, placebo-controlled study in 126 healthy volunteers (35-65 years). Besides the acute effects of single dose cognitaven ® intake also the effects of chronic supplementation of 430 mg, 860 mg, or 1290 mg cognitaven ® for 29 days have been assessed. Working memory and multitasking were assessed in several computer-based tests. The results impressively show, that the acute intake of 1290 mg cognitaven ® improves significantly the working memory from the first day of supplementation as assessed by the Corsi Blocks working memory task. This improvement in working memory performance was also achieved by a chronic intake of the lowest dose of 430 mg cognitaven for 29 days [28]. Our modern life often forces us to do several things at the same time. This multitasking ability is increasingly considered a basic requirement in the 21 st century to cope with the ever-accelerating daily life. In this context, cognitaven ® intake was shown to improve the multitasking performance. In the acute setting intake of the highest dose of 1290 mg cognitaven ® achieved significant effects, while in the chronic setting after 29 days of cognitaven ® intake also the lowest dose of 430 mg cognitaven ® was sufficient [28]. These findings support an intake of a higher dose of cognitaven ® in acute stress situations that require our full concentration and the ability to multitask. For the support of cognitive function in current daily life the intake of 430 mg once to three times a day would be recommended from the results of the study. Support your immune function Ageing concerns the whole body and all organ systems. Therefore, it is not surprising that also our immune system undergoes distinct changes and functional remodelling with increasing age. The term “immunosenescence” refers to the age-related decrease of the immune function and the associated increased susceptibility to infectious diseases in the elderly. As already outlined above, elderly often exhibit chronic low-grade inflammation defined as a higher baseline of pro-inflammatory cytokines in the circulation. Of note, chronic stress reduces various immune functional capacities [6]. Thus, in terms of healthy ageing, support of the immune system also desires attention. One of the best-known plant preparations for this purpose is pressed juice from purple coneflower (Echinacea purpurea (L.) Moench). Purple coneflower is an herbaceous, drought-tolerant perennial plant in the daisy family (Asteraceae) growing in moist to dry prairies and open wooded areas of the Eastern and Central North America. Already, the Native American tribes used plant preparations of coneflower, or just short Echinacea, for cold symptoms, like coughs or sore throats, and as a pain medication, e. g. for toothaches. Photo © : Adobe Stock/luengo_ua A meta-analy sis of 14 randomised placebocontrolled trials that evaluated Echinaceacontaining products in the prevention and/or treatment of the common cold summarised unequivocal beneficial effects. Echinacea decreased the duration of a cold by 1.4 days. Importantly, Echinacea decreased also the odds of contracting a cold by 58 %. Of note, due to the heterogeneity of the studies, the agreement among the studies on the general benefit of Echinacea was clear but not the magnitude of the effect [29]. Later on, another meta-analysis examined six randomised placebo controlled trials of high quality. Schapowal et al. concluded that preparations of Echinacea are suitable for the long-term management of recurrent infections of the respiratory tract as Echinacea compared to placebo reduced the risk for infections. Especially people with lowered immune function and higher susceptibility to infections would benefit most according to their study. Importantly, the authors reported a good safety profile with no biochemical or haematological parameters affected after four months Echinacea consumption [30]. In view of these findings, Echinacea preparations appear as a great support to counteract an impaired immune function in the context of healthy ageing. No fountain of youth but high quality plant extracts Returning to the motif of the fountain of youth, it is evident, that true rejuvenation by consumption of food supplements remains 14 No. 3 November/December 2021

Healthy ageing and mental well-being just a pleasant imagination. Nevertheless, plant-based extracts are clearly useful to maintain the overall well-being and to stay healthy. For a holistic concept to support healthy ageing, Anklam Extrakt GmbH offers several high quality plant extracts and preparations. With Delphinol ® and MaquiBright ® , you support the overall antioxidant capacity of your body’s cells and maintain the health of bones, skin and eyes. For the mental well-being and to keep the pace with today’s sometimes challenging stressful life cognitaven ® and lemon balm extract provide aid to overcome stressful situations and allow you to find restful sleep and relaxation. Not the least, Echinacea dried pressed juice is a well-known immune function supporting plant preparation and also available from Anklam Extrakt GmbH. Whether as a single ingredient or in combination – with these plant extracts, optimal nutritional supplements can be created for every lifestyle. 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A Delphinidin-Enriched Maqui Berry Extract Improves Bone Metabolism and Protects against Bone Loss in Osteopenic Mouse Models. Antioxidants 2019;8:386. antiox8090386. [19] Gayton JL. Etiology, prevalence, and treatment of dry eye disease. Clin Ophthalmol 2009;3:405–12. [20] Tanaka J, Kadekaru T, Ogawa K, Hitoe S, Shimoda H, Hara H. Maqui berry (Aristotelia chilensis) and the constituent delphinidin glycoside inhibit photoreceptor cell death induced by visible light. Food Chem 2013;139:129–37. [21] Hitoe S, Tanaka J, Shimoda H. MaquiBright TM standardized maqui berry extract significantly increases tear fluid production and ameliorates dry eye-related symptoms in a clini cal pilot trial. Panminerva Med 2014;56:1–6. [22] Yamashita S-I, Suzuki N, Yamamoto K, Iio S-I, Yamada T. Effects of MaquiBright ® on improving eye dryness and fatigue in humans: A randomized, double-blind, placebocontrolled trial. J Tradit Complement Med 2019;9:172–8. jtcme.2018.11.001. [23] Committee on Herbal Medicinal Products (HMPC). Assessment report on Melissa officinalis L., folium (EMA/HMPC/196746/2012). European Medicines Agency 2013:1–20. [24] Shakeri A, Sahebkar A, Javadi B. Melissa officinalis L. - A review of its traditional uses, phytochemistry and pharmacology. J Ethnopharmacol 2016;188:204–28. https://doi. org/10.1016/j.jep.2016.05.010. [25] Scholey A, Gibbs A, Neale C, Perry N, Ossoukhova A, Bilog V, et al. Anti-stress effects of lemon balm-containing foods. Nutrients 2014;6:4805–21. nu6114805. [26] Cases J, Ibarra A, Feuillère N, Roller M, Sukkar SG. Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. Med J Nutrition Metab 2011;4:211–8. s12349-010-0045-4. [27] Committee on Herbal Medicinal Products (HMPC). Assessment report on Avena sativa L., herba and Avena sativa L., fructus (EMEA/HMPC/202967/2007). European Medicines Agency 2008:1–21. [28] Kennedy DO, Bonnländer B, Lang SC, Pischel I, Forster J, Khan J, et al. Acute and Chronic Effects of Green Oat (Avena sativa) Extract on Cognitive Function and Mood during a Laboratory Stressor in Healthy Adults: A Randomised, Double-Blind, Placebo-Controlled Study in Healthy Humans. Nutrients 2020;12:1598. [29] Shah SA, Sander S, White CM, Rinaldi M, Coleman CI. Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysis. Lancet Infect Dis 2007;7:473–80. [30] Schapowal A, Klein P, Johnston SL. Echinacea reduces the risk of recurrent respiratory tract infections and complications: a meta-analysis of randomized controlled trials. Adv Ther 2015;32:187–200. For more information, please contact Dr. Annette Masuch, Regulatory Affairs & Project Manager, Anklam Extrakt GmbH No. 3 November/December 2021 15

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