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Wellness Foods + Supplements 1/2023

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Wellness Foods & Supplements is the first European magazine devoted exclusively to health ingredients, nutraceutical foods and beverages. Questions about the trade magazine Wellness Foods & Supplements? Interested in subscribing or advertising? The board of editors at Wellness Foods & Supplements kindly remains at your disposal.

Immune and gut health ©

Immune and gut health © Kemin Industries, Inc. and its group of companies 2023 BetaVia: A natural, postbiotic for immune & gut health Samanta Maci Strong and well-functioning immune and gastrointestinal (GI) systems are essential for staying healthy. Market studies show that consumers recognize the link between poor digestive health and week immunity. Globally, 40 % of consumers suffer from digestive health problems on a regular basis and a survey from 2022 indicated that 66 % and 56 % of global consumers plan to address immune and digestive health in the next twelve months, respectively [1,2]. The GI and immune system are tightly connected, and their balance is essential for good health. The gut is considered the largest immunological organ in the body, controlling - through the intestinal barrier – what needs to “go in” or stays “out” of the body and having a central role in regulating immune homeostasis [3]. Approximately 70 % of the entire immune system is located around the gut [4]. Responses to pathogens, recognition and tolerance of self-antigens, tolerance to commensal microflora, and sensitization/desensitization to food components, all take place in the gut [5]. Among the lifestyle triggers that have been associated with negatively altering intestinal permeability are western diets low in fiber and stress [6]. Interestingly, the disruption of the intestinal barrier integrity is suggested to be the principle behind “leaky gut” - a condition gaining more attention and reportedly more prevalent. Leaky gut has been associated with a wide range of conditions from mild occasional GI symptoms such as bloating, gas and cramping, to more severe conditions including disease states including autoimmune and allergic diseases, food allergies and Inflammatory Bowel Syndrome [7,8]. The integrity and function of the intestinal barrier is influenced by internal and external factors. Bacterial overgrowth and gluten 20 No. 1 April/May 2023

Immune and gut health are known to increased intestinal permeability [9]. Dietary components can also play beneficial roles beyond basic nutrition including the influence of immune and gut health. Beta-glucans (BG) are one such food component that can act via immune-gut health promoting mechanisms [10]. Kemin Human Nutrition and Health has recently introduced in the market BetaVia TM , a clinically studied, natural, postbiotic offering food and beverage and dietary supplement manufacturers the opportunity to address the emerging consumer demand for immune and gut benefits. Product characteristics BetaVia is naturally sourced, algae-based dietary ingredient that supports both the immune and gastrointestinal systems, providing benefits for digestive and respiratory health. This natural and clinically studied ingredient is sustainably produced from a proprietary strain of Euglena gracilis algae through a patented fermentation process (US 9,574,217 B2). Euglena gracilis from Kemin, is grown heterotrophically in closed tanks under controlled conditions. The optimization of this vertically integrated process results in the production of paramylon, granules made exclusively of long chains of linear, nondigestible, beta 1,3 glucan. BetaVia is available in 4 diverse product forms suitable for different applications including water dispersible ones: 2 forms with ≥ 50 % beta 1,3 glucans (on a dry weigh basis) also containing significant quantities of protein (≥ 15 %), and small quantities of fat vitamins, minerals, carotenoids and long-chain polyunsaturated fatty acids naturally present in the Euglena gracilis algae, and 2 forms with ≥ 95 % beta glucan content. BetaVia has an established regulatory status on a global basis and is Kosher, Halal certified as well as vegetarian, gluten-free, allergen-free and non-GMO. Product charac teristics and use is summarized in Table 1. BetaVia– immune & gut promoter In-vitro and in-vivo research indicates that beta 1,3 glucans from Euglena gracilis can play a beneficial role in both immune and gut health through a triple-action protection mechanism [11-15] (Fig 1). Insoluble beta 1,3 glucans are part of a class of molecules known as pathogen-associated molecular patterns (PAMPs) that serve as the critical, “non-self” alert signals recognized by cells of the innate immune system (macrophages, neutrophils, dendritic cells) present in the Peyer’s patches that are the sentinels in body’s natural defense present in the GI. Beta 1,3 glucans from BetaVia can reach the small intestine undigested, be phagocyted by the cells of the innate immune systems, prime these cells and recruit them to the GI tract [12,16]. Table 1: Technical characteristics of BetaVia product forms Parameters BV Complete BV Complete WD BV Pure BV Pure WD Identity Beta 1.3 glucan ≥ 50 % ≥ 50 % ≥ 95 % ≥ 95 % Protein ≥ 15 % ≥ 15% 0% 0% Flavor Algae Algae Neutral Neutral Color Golden Golden White White Adult Daily Dose 375 mg 375 mg 200 mg 200 mg Application Capsules, Tablets, Syrup, Sticks, Bars Softgels, gummies Capsules, Tablets, Sticks, Syrups, Bars Sticks, RTDs, gummies, softgels Microbiological Tests Aerobic Plate Count (CFU/g) Yeast and Mold (CFU/g) Coliforms(mpn/g) E.coli Salmonella Staphylococcus aureus L. monocytogens Conform to technical specifications No. 1 April/May 2023 21

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