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Wellness Foods + Supplements 1/2022

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Wellness Foods & Supplements is the first European magazine devoted exclusively to health ingredients, nutraceutical foods and beverages. Questions about the trade magazine Wellness Foods & Supplements? Interested in subscribing or advertising? The board of editors at Wellness Foods & Supplements kindly remains at your disposal.

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Cover story Photo © : Adobestock/eAlisa Urinary health maintenance, a goal for millions of people With Indena’s Anthocran ® Phytosome ® let’s shed new light on urinary tract health, enhancing cranberry potential More than 150 million people annually (1), are affected by urinary tract infections (UTIs) which are among the most frequent infections in clinical practice worldwide. UTIs can affect any part of the urinary system although the organs where they most frequently develop are the bladder and urethra. Such infections create clinical and economic burdens on healthcare systems, and negatively influence individuals’ quality of life as well. Recurrent lower urinary tract infections (R-UTIs) are common after urinary catheterization in surgical patients, but they may occur also in non-surgical patients, particularly in women, and are also common in men. Cranberry products have beneficial role for urinary tract wellbeing because they can control R-UTIs episodes frequencies, as observed by several studies. The complex mixture of proanthocyanidins (PACs), flavonols and phenolicacids contained in cranberry extract seems to level biofilm formation and tissues pricking. On the other hand, cranberry extract presents a problem of poor availability and bioabsorption, like many other natural compounds. That’s why Indena has developed a new health-food ingredient based on Phytosome ® formulation proprietary technology, able to enhance and optimize the delivery of Indena’s cranberry extract (Anthocran ® Phytosome ® ) where the effects are needed. In addition to its better ability to reach tissues, thanks to the phytosome ® 100 % food grade formulation, cranberry extract (Anthocran ® Phytosome ® ) boasts a unique phytochemi cal characterization, which makes it the highest quality cranberry extract on the market; infact, it is standardized in proanthocyanidins (PACs: 6.0-9.0 % UV-visible spec- 6 No. 1 April/May 2022

Cover story trophotometric contents – DMAC method) and contains the full polyphenols profile of natural cranberry, including flavonols, anthocyanins and phenolic acids. A recent human urines pharmacokinetics study (2) has been done with the aim to profile, by using an HPLC-MS/MS method, cranberry compounds and metabolites found in human urine after supplementation of a highly standardized cranberry extract: Anthocran ® Phytosome ® . Two different strategies were adopted for the data analysis: a targeted and an untargeted approach. These strategies allowed the identification of 42 analytes including cranberry components, known metabolites and metabolites hitherto unreported in the literature, including eight valerolactones/valeric acid derivatives whose presence in urine after cranberry consumption has never been described before. Moreover, the ex vivo study showed that urine fractions rich in these metabolites are the most active against the pathogen Candida so frequent in hospitalized patients; it can reach the 10 % of positive urine cultures in hospitals, intensive care units and tertiary care facilities. To support from a clinical point of view these interesting data, a pilot registry study (3) recently investigated the effects of the oral supplementation of a standardized Anthocran ® Phytosome ® for the support of urinary tract health. reported to have a more favorable actions in managing UTI discomforts (like urinary frequency, urinary urgency, dysuria and nocturia), as assessed on the visual analogue scale, compared with subjects in the standard management or nitrofurantoin groups. No subjects with blood in urines and with traces of bacterial infection in urine in the group treated with the supplement compared with controls (p < 0.05). The cranberry extract was also superior to the control management in terms of recurrence of signs, with none of the subjects in this group reporting a R-UTI in the 3-months following the study end (p < 0.05). The supplementation showed an optimal safety profile, with no significant adverse events and no drop-outs in the supplement group. The study shows that cranberry extract (Anthocran ® formulated as Phytosome ® ) is a valid diet supplementation for subjects where postoperative, post-catheter R UTIs may occur, whit a good tolerability profile. References 1 World J Urol. 2020 Nov;38(11):2669-2679. doi: 10.1007/s00345-019-03071-4. Epub 2020 Jan 10.) 2 Giovanna Baron et alii, Biochemical Pharmacology 173 (2020) 113726 3 Roberto Cotellese, Andrea Ledda, Gianni Belcaro, Maria R. Cesarone, Claudia Scipione, Valeria Scipione, Mark Dugall, Beatrice Feragalli, Antonella Riva, Pietro Allegrini, Giovanna Petrangolini & Stefano Togni (2021):, DOI: 10.1080/19390211.2021.1972074 For more information, please contact Laura Bo External Communication and Sustainability, Indena S.p.A. laura.bo@indena.com www.indena.com The study included 64 otherwise healthy subjects who underwent a surgical procedure and required post-surgical urinary catheterization. The subjects have been divided by randomization in four groups: 12 subjects were given supplementation with the standardized cranberry extract at the dose of either 120 mg/day, 12 subjects at 240 mg/day, 18 subjects were assigned to a control group consisting of standard management and 22 to a group with nitrofurantoin administration for four weeks to relief the R UTIs. At the end, subjects receiving the standardized cranberry Phytosome ® supplementation No. 1 April/May 2022 7

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