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Wellness Foods + Supplements 1/2022

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Wellness Foods & Supplements is the first European magazine devoted exclusively to health ingredients, nutraceutical foods and beverages. Questions about the trade magazine Wellness Foods & Supplements? Interested in subscribing or advertising? The board of editors at Wellness Foods & Supplements kindly remains at your disposal.

Microbiome rides,

Microbiome rides, disaccharides, monosaccharides, and polyols). The effect of Sunfiber ® on diet-related diseases has been demonstrated in more than 150 studies. For example, in a recent internal report 7 together with Probionova ® , the results for Lactobacillus spp. indicate that almost all microorganisms can actively grow in the presence of Sunfiber ® . MicrobiomeX ® is an example of a fruit extract with high flavonoid content and prebiotic effect. This first-in-class product combines active ingredients from Citrus Sinensis (Orange) and Citrus Paradisi (Grapefruit). The unique complex is specifically designed to positively alter the gut microbiome to support gut health and immune system, reduce intestinal inflammation and strengthen the gut barrier. MicrobiomeX ® has been validated in multiple proprietary studies showing a dose-dependent beneficial effect with a daily intake ranging from 250 to 500 mg. In addition, the significant shift in SCFA profile and the lower calprotectin levels observed suggest a decreased pathogen load in the gut. Probionova is one of the most innovative companies focusing on the microbiome by developing new probiotic applications. The young, future-oriented partner company of Vivatis ® maintains a leading scientific position in the research and development of new probiotics/synbiotics. With its in-depth experience, the company can select the best strain or an optimum synergy of the available strains to provide customers with the highest quality standards and customized offers. Probionova ® has specialized in responding to the most diverse wishes and requirements for probiotics products. The range extends from various unique probiotic strains to finished products that are good for the microbiome. Difference in Butyrate/total SCFA ratio after 12 weeks of intervention Butyrate & total SCFA ratio 0.025 0.02 0.015 0.01 0.005 0 -0.005 -0.01 -0.015 Intervention Placebo MicrobiomeX ® * *Significant effect on SCFA ratio after daily application of MicrobiomeX ® Today, customized product solutions are increasingly in demand for prebiotic and probiotic products instead of all-in-one products. They make it easier to meet the diverse requirements of the human organism, minimize side effects and provide targeted support for specific areas. The current state of research and product development is bringing into light a growing number of facts about the diversity of probiotic strains. They are designed or synergistically combined with high quality and concentration for the application and function. References 1 “Identifying personal microbiomes using metagenomics codes”, Eric A. Franzosa, Katherine Huang, James F. Meadow, Dirk Gevers, Katherine P. Lemon, Brendan JM Bohannan, Curtis Huttenhower, 2 “Arrhythmic Gut Microbiome Signatures Predict Risk of Type 2 Diabetes” 3 Schaupp L et al. Microbiota-induced type I interferons instruct a poised basal state of dendritic cells. Cell 2020 Mai 06. doi: https://doi.org/10.1016/j.cell.2020.04.022 4 Wilmanski, T., Diener, C., Rappaport, N., Patwardhan, S., Wiedrick, J., Lapidus, J., & Price, N. D. (2021). Gut microbiome patternreflects healthy ageing and predicts survival in humans. Nature metabolism, 3(2), 274-286. 5 “The gut microbiota influences skeletal muscle mass and function in mice”, Shawon Lahiri et al.; Science Translational Medicine, DOI: 10.1126/scitranslmed.aan5662 6 Aguilar-Toalá, J. E. et al. Postbiotics — when simplification fails to clarify. Nat. Rev. Gastroenterol. Hepatol. https://doi.org/10.1038/s41575-021-00521-6 (2021). 7 “Probionova report” (2020) Evaluation-of-the-prebioticpotential-of-Sunfiber For more information, please contact Diana Kalustova, Business Development Manager Nutraceuticals, Vivatis Pharma GmbH Hamburg, Germany 18 No. 1 April/May 2022

Bioactives for stress and sleep wellbeing Lactium ® , a natural bioactive for mental wellbeing praised by its consumers! How does stress affect our mental health? Stress is part of our modern life: 90 % of the global population regards itself as being stressed. Furthermore, WHO statistics were estimating a worldwide 264 million people to be affected by anxiety disorders. Those statistics were last estimated in 2017, way before covid-19 turned our lives upside down and the global demand for stress-relief aids sky-rocketed. 95 % of the global population recognize that stress and anxiety have an impact on health. With the pandemics, awareness soared on how stress can impact mental health conditions including depression, anxiety, psychosis and post-traumatic stress disorder (PTSD). Lactium ® : a natural ingredient to help manage stress and sleep disorders Lactium ® is go-to solution for natural products lovers. With no addiction or side effects, this natural milk protein hydrolysate contains a bioactive peptide with relaxing properties called alpha-casozepine. Lactium ® acts as an anxiolytic with an affinity for the GABAA receptor, more specifically for its benzodiazepine site. 9 clinical trials on more than 500 volunteers have already demonstrated Lactium ® efficacy on stress issues and sleep disturbances, with a recognition by the scientific community through several published articles. In 2021, those were completed by a consumer study to address a core objective for all our customers: consumer satisfaction. 8 consumers in 10 are satisfied with Lactium ® Our latest study was performed on 300 healthy volunteers, recruited in USA, France and China for their suffering from moderate stress and sleep disturbances. They received a 300 mg dose for 30 days and their feedbacks were recorded through validated questionnaires performed by Mérieux Nutrisciences. We were proud to receive results showing an overall 78 % satisfaction, quite evenly split in 78 % for moderate stress and 77 % for sleep disturbances. More claims for Lactium ® As we’ll explain in our conference, this consumer study enables new claims on packaging or ad prints for our customers. It will complete the previously obtained 7 US FDA structure function claims and 2 South Korean claims. Happy consumers’ recognition is now adding to Lactium ® ’s solid scientific background for its efficacy on stress and sleep improvement, in a world where mental health has become so central to our lives. Incorporated for more than 20 years in over 300 products, Lactium ® provides a natural way to regain plain serenity! Please visit Ingredia at Vitafoods in Geneva May 10 – 12, 2022 booth G100 No. 1 April/May 2022 19

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